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This bacterial shift can happen within weeks of sustained dry mouth and can persist even after saliva flow normalizes, because the new bacterial colonies have established themselves

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Clinical data on tirzepatide in type 2 diabetes—the SURPASS clinical trial program Early clinical studies with tirzepatide revealed a marked and dose-dependent reduction of HbA1c and further glycemic parameters in patients with T2D in various ethnic cohorts (clinical trials registration numbers NCT03322631, NCT03131687, and NCT03311724) (66–68)